Father of Green Nanotechnology

  • Professor of Radiology and Physics & Medical Research
  • Director, Institute of Green Nanotechnology. Medical School-University of Missouri, USA
  • Chairman: Nano-Radio-pharmaceuticals. UNโ€“ IAEA RCM
  • Member: Global Experts Committee for Green Nano Technology - United Nations
  • Elected Member - National Academy of Inventors. USA (2015)
  • Inventor of โ€˜Katti Peptidesโ€™ a group of peptides used in biomedical sciences
  • Hevesy Medal Award (on par with the Nobel Prize in Nuclear Sciences)
  • Over 175 inventions / Over 50 patents
TECHNICAL DETAILS
  • Silver nanoparticles with herbal extracts
  • Size: in between 1-100 nm
  • 100% Natural Product (Chemical Free)
  • 100% Water soluble
  • 100% Non-Toxic
  • 100% Gluten Free
  • Very rich green antioxidant
  • Strong anti-fungal/microbial in nature
  • Kills 99.99% bacteria & even super-bugs (MRS) within 60 seconds
  • No special precautions
  • Generally safe for use
  • Non Alcoholic
  • Halal certified
PHYSICAL & CHEMICAL PROPERTIES
  • Physical state : Solution
  • Colour : Color varies from dark yellow to brownish yellow to brown
  • Odour : Characteristic
  • pH : 2.0 to 5.0
  • Specific gravity : 0.96 to 1.10
  • Silver content : 158 to 193 ppm
  • Absorbance : 0.5 to 2.5
  • Particle size : Core size (TEM)= 30 ยฑ 10 nm
  • Zeta potential : -5 to -35 mV
  • Freezing point : -5
  • Boiling point : 110
  • Flammability (solid, gas) : Non inflammable
  • Solubility Water : Miscible in water
  • Viscosity : 1 cps at 20
  • Chemical family : Noble metals

EFICACY

Gram Positive Bacteria

  • Staphylococcus aureus (Methicillin-resistant)
  • Staphylococcus epidermidis
  • Bacillus subtilis
  • Enterococcus faecalis
  • Streptococcus mutans
  • Clostridium perfringens

Gram Negative Bacteria

  • Escherichia coli
  • Pseudomonas aeruginosa
  • Acinetobacter baumannii
  • Salmonella enteritica
  • Klebsiella aerogenes
  • Shigella flexneri and yeast
  • Candida albicans
Micro-organism ATCC Number MIC (๐๐’ˆ/๐’Ž๐’) MBC (๐๐’ˆ/๐’Ž๐’) EC50 (๐๐’ˆ/๐’Ž๐’)
Escherichia coli 12435 5 10 3.5
Pseudomonas Aeruginosa 15442 5 5 3
Enterobacter Aerogenes 13048 10 10 4
Acinetobacter Baumannii 19606 5 10 2
Staphylococcus Aureus 25923 10 โ‰ˆ20 4
Staphylococcus Epidermidis 35984 5 20 4
Bacillus Subtilis 6051 5 20 2
Enterococcus Faecalis 29212 5 5 3
Candida Albicans 10231 10 5 0.16
  • MIC- Minimum inhibitory concentration-lowest concentration of an antibacterial agent necessary to inhibit visible growth
  • MBC- Minimum bactericidal concentration-lowest concentration of silver nanoparticles to prevent growth
  • Destroy the most deadly bacteria - Methicillin-resistant Staphylococcus aureus (MRSA).
  • EC50- concentration of a drug that gives half-maximal response

TOXICITY

  • Acute toxicity: LD 50 > 10 ml / kg (Silver equivalent 1700 mcg) body weight- in rats and mice.
  • Repeated dose toxicity: NOAEL (No Observed Adverse Effect Level) of silver nanoparticles is considered to be 10 ml/kg (Silver equivalent 1700 mcg) body weight in both rabbits and rats

SINGLE DOSE ORAL TOXICITY

Sprague Dawley Rats & Swiss Albino Mice

  • Guidlines - As per Schedule Y
  • Result - LD50 is > 10 ml/kg body weight

REPEATED DOSE TOXICITY FOR 28 DAYS

Sprague Dawley Rats & New Zealand White Rabbits

  • Guidlines - As per Schedule Y
  • Result - LD50 is > 10 ml/kg body weight

ACUTE EYE IRRITATION STUDY

New Zealand White Rabbits

  • Guidlines - OCED
  • Result - Non-irritant